Welcome to Serio’s Pharmacy

Your health. Our priority.

Your Pharmacy Experts

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Located in Northampton, MA we’ve been serving the communities of Northampton, Florence, and Leeds since 1949. Our pharmacy staff have a combined 100 years of experience, and our friendly staff will treat you like family. Learn more

Read Our Patient Reviews

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Shayne T.

" Nothing beats a local mom and pop pharmacy. The customer service is so much better. You see them same folks each time and you are supporting a small local business. I really encourage everyone to make the switch to support these folks that are keeping our community healthy."

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Andrea L.

" This multi-generational family-owned pharmacy is a throwback to the era before large department stores and pharmacy chains. Knowledgeable and friendly staff members know their customers. If you can get your prescription elsewhere for less, they will tell you."

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Daniel S.

" Every time I go into Serios it makes me incredibly happy and relieved to be able to go there instead of one of the chains. They're thoughtful, kind, on the ball, and the prices are very good. Just the best"

Get In Touch

63 State St Northampton, MA 01060
Mon-Wed-Fri: 9:00 AM - 6:00 PM
Tue-Thur: 8:30 AM - 6:00 PM
Sat: 9:00 AM - 1:00 PM
Sun: Closed

Phone: (413) 584-8980 | Fax: (413) 584-6027
Email: seriosrx@yahoo.com

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Manage your care from any device

Access your Patient Portal

Serio's Pharmacy’s patient portal gives you easy access to essential pharmacy services — anytime, anywhere.

  • Request refills
  • Chat with our team
  • Schedule appointments
  • Manage family members

At Serio's Pharmacy, we’re proud to offer personalized, user-friendly tools to support your health. Install our Patient Portal on your personal device today and simplify the way you manage your care.

Access the Patient Portal from your home screen

It's quick and easy to install the Patient Portal to your device! Click below for step-by-step instructions on how to make our portal appear on your iPhone or Android home screen so you can manage your care with just a single click.


View the instructions
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